Is PE-22-28 FDA approved?
No. This profile records PE-22-28 as not FDA approved and for research use only.
MORE CONTEXT ›
Review the regulatory and source details on this page for the current context.
Healing CATEGORY
PE-22-28
THE RAPID MOOD LIFTER
Spadin Analog; Shortened Spadin
PE-22-28 is a synthetic peptide derived from spadin that blocks TREK-1 potassium channels in the brain. This produces rapid antidepressant effects, often within days rather than the weeks typical of SSRIs. It promotes neurogenesis, protects neurons, and may help with stroke recovery. It's an exciting option for those seeking fast-acting mood support.
PE-22-28
PE-22-28
PE-22-28
PE-22-28 Evidence Snapshot
How these guides are reviewed
REGULATORY STATUS
Not FDA approved · research use only
DOSING GUIDANCE
Reviewed by our clinical team
LINKED EVIDENCE
1 research sources
CONTENT UPDATED
Aug 28, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About PE-22-28
What dose does The Peptide App Clinical Team recommend for PE-22-28?
Dose: 400 mcg intranasally each morning.
MORE CONTEXT ›
Schedule: daily. Cycle: 4 weeks on, 4 weeks off. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this PE-22-28 guide?
This guide links to 1 curated or current research sources.
MORE CONTEXT ›
Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Studied Effects & Mechanisms
TREK-1 Blockade
Blocks potassium channels to stabilize neuronal membrane
Rapid Neurogenesis
Induces new brain cell growth within days
BDNF Upregulation
Increases brain-derived neurotrophic factor
Serotonin/Dopamine
Modulates monoamine neurotransmitter pathways
Those seeking rapid mood improvement
People who haven't responded to traditional antidepressants
Stroke recovery patients
Those interested in neurogenesis
Anyone wanting faster-acting mood support
PE-22-28 Research
Live research temporarily unavailableThe live research feed did not return papers for this page. The curated references below remain available for crawlable source context.
RESEARCH REFERENCES