Is Tesofensine FDA approved?
No. This profile records Tesofensine as not FDA approved and for research use only.
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Review the regulatory and source details on this page for the current context.
Metabolic CATEGORY
Tesofensine
THE APPETITE CRUSHER
TE-1; NS2330
Tesofensine is a triple monoamine reuptake inhibitor that was originally developed for Parkinson's and Alzheimer's. It blocks reuptake of dopamine, norepinephrine, and serotonin, powerfully reducing appetite and increasing energy expenditure. In trials it produced greater weight loss than any other single agent, making it one of the most effective compounds for obesity.
Tesofensine
Tesofensine
Tesofensine
Tesofensine Evidence Snapshot
How these guides are reviewed
REGULATORY STATUS
Not FDA approved · research use only
DOSING GUIDANCE
Reviewed by our clinical team
LINKED EVIDENCE
1 research sources
CONTENT UPDATED
Sep 1, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Tesofensine
What dose does The Peptide App Clinical Team recommend for Tesofensine?
Dose: 0.25-0.5 mg orally once daily.
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Schedule: daily. Cycle: Ongoing with medical supervision. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this Tesofensine guide?
This guide links to 1 curated or current research sources.
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Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Studied Effects & Mechanisms
Triple Reuptake Inhibition
Blocks DAT, NET, and SERT transporters
Appetite Suppression
Increases monoamines in hypothalamic feeding centers
Thermogenesis
Enhances sympathetic activity and energy expenditure
Cognitive Enhancement
Improves dopamine-mediated focus and motivation
Those with significant weight to lose
People who struggle with appetite control
hose who haven't responded to other weight loss drugs
Anyone wanting cognitive boost alongside weight loss
Tesofensine Research
Live research temporarily unavailableThe live research feed did not return papers for this page. The curated references below remain available for crawlable source context.
RESEARCH REFERENCES