Is Orexin A and Orexin B FDA approved?
No. This profile records Orexin A and Orexin B as not FDA approved and for research use only.
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Review the regulatory and source details on this page for the current context.
Metabolic CATEGORY
Orexin A and Orexin B
THE WAKEFULNESS PROMOTER
Hypocretins
Orexins are neuropeptides produced in your hypothalamus that control wakefulness, hunger, and stress responses. Orexin deficiency causes narcolepsy. That's how important they are for staying awake and alert. Supplementing with orexins can boost daytime alertness, regulate appetite, and help normalize disrupted sleep-wake cycles.
Orexin A and Orexin B
Orexin A and Orexin B
Orexin A and Orexin B
Orexin A and Orexin B Evidence Snapshot
How these guides are reviewed
REGULATORY STATUS
Not FDA approved · research use only
DOSING GUIDANCE
Reviewed by our clinical team
LINKED EVIDENCE
1 research sources
CONTENT UPDATED
Aug 28, 2026
Dose and schedule recommendations shown below come from The Peptide App Clinical Team. Research links are provided so readers can inspect the supporting evidence directly. Review the sources.
Quick Answers About Orexin A and Orexin B
What dose does The Peptide App Clinical Team recommend for Orexin A and Orexin B?
Dose: 100 mcg intranasally each morning.
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Schedule: daily. Cycle: 4 weeks on, 4 weeks off. This is clinical-team guidance for reference and does not replace individualized instructions from a licensed clinician.
What research supports this Orexin A and Orexin B guide?
This guide links to 1 curated or current research sources.
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Open the research section to inspect the source titles, publication details, study types, and available abstracts directly.
Studied Effects & Mechanisms
Wake Promotion
Activates wake-promoting neurons in the hypothalamus
Appetite Regulation
Modulates hunger signals through NPY/AgRP pathways
Cognitive Enhancement
Improves attention and cognitive performance
Stress Response
Modulates HPA axis and sympathetic nervous system
Those with excessive daytime sleepiness
People wanting sharper daytime alertness
Those with disrupted circadian rhythms
People interested in appetite regulation
Night shift workers needing schedule adjustment
Orexin A and Orexin B Research
Live research temporarily unavailableThe live research feed did not return papers for this page. The curated references below remain available for crawlable source context.
RESEARCH REFERENCES