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Sculpt & Burn

Intermediate Friendly
28 week cycle
2 peptides
76 starts

SCHEDULE GUIDE

What does the MOTS-c and Retatrutide protocol include?

The Sculpt & Burn protocol combines Retatrutide and MOTS-c in a structured 28-week schedule divided into four phases. The protocol progresses through initiation, active fat loss, consolidation, and tapering phases. Each phase adjusts the protocol structure over time, creating a progressive approach designed around weight management and metabolic optimization goals. Review the complete schedule and individual peptide information before beginning any protocol.

CYCLE
28 Weeks
STRUCTURE
4 phases
COMPOUNDS
2 peptides
APP HANDOFF
Started by 76 people

Overview

Combines Retatrutide and MOTS-c in a structured 28-week, four-phase protocol focused on weight management and metabolic optimization. The stack progresses through initiation, active fat loss, consolidation, and tapering phases, pairing a metabolic-focused compound with a mitochondrial-targeting peptide.

Stack Synergy

Retatrutide and MOTS-c are paired to create a complementary approach to weight management and metabolic optimization. Retatrutide — The Driver: Serves as the primary component of the stack, supporting the protocol's focus on body composition and metabolic goals. MOTS-c — The Optimizer: Complements the protocol with a focus on mitochondrial function, cellular energy, and metabolic activity. Together, the Sculpt & Burn stack combines a metabolic-focused peptide with a mitochondrial-targeting peptide across a phased 28-week schedule.

Benefits

› Supports comprehensive weight management goals
› Designed around metabolic optimization
› Supports efforts to improve body composition
› Combines metabolic and mitochondrial-focused peptides
› Structured phased approach over 28 weeks
› Supports focus on cellular energy and metabolic activity
› Includes progression from initiation through tapering

Peptides in This Protocol

Planning the source side of a stack? Compare current peptide prices by vial size before reviewing individual peptide profiles.

MOTS-c

Grade B
THE METABOLIC MESSENGER

Retatrutide

Grade C
THE GAME CHANGER

Phase Timeline

Initiation

Days 1–14 Includes 14 hold days
The introductory phase establishes the Sculpt & Burn protocol with both Retatrutide and MOTS-c.

Begin with the published schedule and review all protocol details before progressing to the next phase.

Retatrutide
Start at 0.5 mg weekly, titrate to 2.5-5 mg weekly weekly
MOTS-c
5-15 mg injected 2-3 times weekly twice_weekly

Active Fat Loss

Days 15–70 Includes 14 hold days
The primary active phase increases the protocol structure to support the stack's weight management and metabolic optimization focus.

Follow the published phase structure and review individual peptide details before making changes.

Retatrutide
Start at 0.5 mg weekly, titrate to 2.5-5 mg weekly weekly
MOTS-c
5-15 mg injected 2-3 times weekly twice_weekly

Consolidation

Days 71–154 Includes 14 hold days
A consolidation phase that continues the structured protocol while transitioning away from the more intensive active phase.

Continue monitoring the protocol structure and review progress before transitioning into the taper phase.

Retatrutide
Start at 0.5 mg weekly, titrate to 2.5-5 mg weekly weekly
MOTS-c
5-15 mg injected 2-3 times weekly twice_weekly

Taper

Days 155–196 Includes 14 hold days
The final phase gradually reduces the protocol structure as the published 28-week schedule approaches completion.

Review the complete protocol and individual peptide information before concluding the schedule.

Retatrutide
Start at 0.5 mg weekly, titrate to 2.5-5 mg weekly weekly

Who Is This For

Intermediate Level

The Sculpt & Burn protocol is positioned for intermediate-level individuals interested in a structured approach to weight management, body composition, and metabolic optimization. The combination of Retatrutide and MOTS-c may appeal to individuals who are focused on long-term body composition goals and want a phased protocol that progresses from initiation through active and consolidation periods. This protocol involves multiple phases over a 28-week period, making it important to review the structure, individual compounds, and available research before considering the published schedule.

More questions about this schedule

What is the Sculpt & Burn protocol?

Sculpt & Burn is a 28-week phased protocol that combines Retatrutide and MOTS-c. The stack is structured around weight management, body composition, and metabolic optimization goals.

Which peptides are included in Sculpt & Burn?

The Sculpt & Burn stack includes two peptides: Retatrutide and MOTS-c. In the reference structure, Retatrutide is labeled “The Driver” and MOTS-c is labeled “The Optimizer.”

How long is the Sculpt & Burn protocol?

The published Sculpt & Burn schedule runs for 28 weeks and is divided into four phases: Initiation, Active Fat Loss, Consolidation, and Taper.

How many phases are in the Sculpt & Burn protocol?

The protocol contains four phases. Each phase has a different duration and schedule structure as the protocol progresses across the full 28-week timeline.

What is the purpose of the Initiation phase?

The Initiation phase introduces both Retatrutide and MOTS-c into the published protocol structure and establishes the starting point for the longer phased schedule.

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