Energy Boost
Intermediate FriendlyWhat does the NAD+, SS-31 and MOTS-c protocol include?
This protocol pairs three peptides across a three-phase, 12-week schedule and gives each one a distinct job: NAD+ supplies the raw fuel cells need for energy production, SS-31 protects the mitochondrial membrane so that fuel doesn't leak away as damage or inflammation, and MOTS-c sends the metabolic signal that helps the body adapt to and use that energy more efficiently. The phases build gradually — starting with a lighter foundation, stepping up to full working amounts, then holding at that level to consolidate the response. These role labels describe how the stack is structured, not a guarantee of outcome. Review the safety information for each peptide individually before starting.
Overview
NAD+, SS-31, and MOTS-c combined in a phased 12-week schedule to protect, fuel, and optimize cellular energy production — built for people dealing with fatigue or age-related energy decline who want to rebuild vitality from the mitochondria up.
Stack Synergy
NAD+ and SS-31 are frequently paired because they address two different sides of the same mitochondrial problem: NAD+ is a coenzyme cells need for energy metabolism, while SS-31 is associated with protecting the inner mitochondrial membrane from the oxidative stress that energy production itself creates. Supplying more fuel without protecting the machinery that uses it is one reason energy-support stacks pair the two rather than running NAD+ alone. MOTS-c is layered on top as the signaling piece. It's a mitochondrial-derived peptide associated with metabolic adaptation — helping the body respond to the increased energy availability from NAD+ and the improved mitochondrial resilience from SS-31 by actually using that capacity more efficiently, rather than just having more raw material on hand. Together, the three are positioned as a "fuel, protect, and adapt" combination aimed at cellular energy production rather than a single symptom like tiredness.
Benefits
Peptides in This Protocol
Planning the source side of a stack? Compare current peptide prices by vial size before reviewing individual peptide profiles.
NAD+
SS-31
MOTS-c
Phase Timeline
Foundation
Days 1–28 NoneTake SS-31 and NAD+ in the morning 5 days a week, and MOTS-c twice a week at a flexible time. Track energy and fatigue as a baseline.
Active Optimization
Days 29–56 NoneContinue the morning schedule for SS-31 and NAD+. Increase MOTS-c to 4 days a week. Note any changes in stamina or recovery.
Consolidation
Days 57–84 2-day hold at the end of the phaseKeep the same schedule through day 84, then hold for 2 days before deciding whether to repeat, adjust, or stop the cycle.
Who Is This For
This protocol is built for intermediate users who already have some peptide experience and want to address energy and stamina at a cellular level rather than reaching for stimulants. It suits people experiencing ongoing fatigue, a noticeable drop in physical performance, or age-related energy loss who want a structured approach to restoring vitality. It's a reasonable fit if you've ruled out more obvious causes of fatigue (sleep, nutrition, stress) and want to target mitochondrial function directly. It's not intended as a substitute for medical evaluation if fatigue is severe, sudden, or accompanied by other symptoms — talk to a healthcare provider if that applies to you.
More questions about this schedule
Why is MOTS-c dosed differently than NAD+ and SS-31?
MOTS-c is scheduled 2–4 times a week rather than daily, which reflects how this peptide is typically used, while NAD+ and SS-31 follow a near-daily morning rhythm.
Can I combine Energy Boost with a weight-management protocol like Sculpt & Burn?
Both involve MOTS-c, so check for overlapping dosing before running the two together rather than assuming they simply stack.
How long until I notice a difference in energy levels?
Most people don't expect meaningful change until well into Phase 2, since Phase 1 is designed to build tolerance rather than produce noticeable effects.
Do I need to increase doses exactly as scheduled?
The phase amounts are a published starting point — you should review and adjust based on how you respond before locking in your own schedule.
Is this protocol appropriate for beginners?
It's labeled Intermediate because it combines three peptides with different roles and a 12-week commitment; beginners may want to start with a single peptide first.
What happens after the 12-week cycle ends?
Most users take a break before considering another cycle and reassess whether the full stack still fits their energy and recovery needs.
